RECENT PUBLICATIONS

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Histological validation of a type 1 diabetes clinical diagnostic model for classification of diabetes.

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A.L.J.Carr, D.J.Perry, A.L.Lynam, S Chamala, C.S.Flaxman, S.A.SHarp, L.A.Ferrat, A.G.Jones, M.L.Beery, L.M.Jacobsen, C.H.Wasserfall, M.L.Campbell-Thompson, I.Kusmartseva, A.Posgai, D.A.Schatz, M.A.Atkinson, T.M.Brusko, S.J.Richardson, B.M.Shields, R.A.Oram

Vitamin D-binding protein contributes to the maintenance of α-cell morphology and function

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Katrina Viloria, Daniela Nasteska, Linford J.B.Briant, Silke Heising, Dean P.Larner, Nicholas H.F.Fine, Fiona B. Ahsford, Gabriela da Silva Xavier, Maria Jiménez Ramos, Annie Hasib, Federica Cuozzo, Jocelyn E. Manning Fox, Patrick E,MacDonald, Iidem Akerman, Gareth G.Lavery, Christine Flaxman, Noel G. Morgan, Sarah J. Richardson, David J.Hodson

An integrated multi-omics approach identifies the landscape of interferon-α-mediated responses of human pancreatic beta cells.

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Maikel L. Colli, Mireia Ramos-Rodríguez,Ernesto S . Nakayasu, Matia I.Alvelos, Miguel Lopes, Jessica L.E.Hill, Jean-Valery Turantsinze, Alexandra Coomans de Brachène, Mark A Russell, Helena Raurell-Vila, Angela Castela, Jonàs Juan-Mateu, Bobbie-Jo M. Webb-Robertson, Lars Krogvold, Knut Dahl-Jorgenses, Lorella Marselli, Piero Marchetti, Sarah J Richardson, Noel G Morgan, Thomas O.Metz, Lorenzo Pasquali, Décio L. Eizirik.

Reduced Expression of the Co-regulator TLE1 in Type 2 Diabetes Is Associated with Increased Islet α-Cell Number

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Sarah L Armour, Scott J Anderson, Sarah J Richardson, Yuchun Ding, Chris Carey, James Lyon, Rashmi R Maheshwari, Najwa Al-Jahdami, Natalio Krasnogor, Noel G Morgan

Optimizing beta cell function through mesenchymal stromal cell-mediated mitochondria transfer

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Chloe L Rackham, Ella L Hubber, Anna Czajka, Afshan N Malik, Pete M Jones

Studies of insulin and proinsulin in pancreas and serum support the existence of aetiopathological endotypes of type 1 diabetes associated with age at diagnosis

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Pia Leete, Richard A Oram, Timothy J McDonald, Beverley M Shields, Clemens Ziller, TIGI Study Team, Andrew T Hattersley, Sarah J Richardson, Noel G Morgan

Rationale for enteroviral vaccination and antiviral therapies in human type 1 diabetes.

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Jessica L Dunne, Srah J Richardson, Mark A Atkinson, Maria E Craig, Knut Dahl-Jørgensen, Malin Flodström-Tullberg, Heikki Hyöty, Richard A Insel, Åke Lernmark, Richard E Lloyd, Noel G Morgan, Alberto Pugliese

Upregulation of HLA Class I and Antiviral Tissue Responses in Hashimoto's Thyroiditis

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Therese Wieder, Sarah J Richardson, Noel G Morgan, Trond H Paulsen, Knut Dhal-Jørgensen, Sara Salehi Hammerstad

In Situ Analysis Reveals That CFTR Is Expressed in Only a Small Minority of β-Cells in Normal Adult Human Pancreas

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Michael G. White, Rashmi R Maheshwari, Scott J Anderson, Rolando Berlinguer - Palmini, Claire Jones, Sarah J Richardson, Pavana G Rotti, Sarah L Armour, Yuchun Ding, Natalio Krasnogor, John F Engelhardt, Mike A gray, Noel G Morgan, James A M Shaw

Differential effects of saturated and unsaturated fatty acids on autophagy in pancreatic β-cells

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Shalinee Dhayal, Francesco P Zummo, Matthew W Andreson, Patricia Thomas, Hannah J Welters, Catherine Arden, Noel G Morgan

Evidence that a STAT3 Mutation Causing Hyper IgE Syndrome Leads to Repression of Transcriptional Activity

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Sameer Bahal, Maha E Houssen, Ania Manson, Lorena Lorenzo, Mark A. Russell, Noel G Morgan, Fariba Tahami, Sofia Grigoriadou

What the HLA-I! – Classical and Non-classical HLA Class I and Their Potential Roles in Type 1 Diabetes

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Rebecca C.Wyatt, Giacomo Lanzoni, Mark A. Russell, Van Gerling & Sarah Richardson

Molecular Pathways for Immune Recognition of Preproinsulin Signal Peptide in Type 1 Diabetes Diabetes 2018 Jan; db170021

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Deborah Kronenberg-Versteeg, Martin Eichmann, Mark A. Russell, Arnoud de Ru, Beate Hehn, Norkhairin Yusuf, Peter A. van Veelen, Sarah J. Richardson, Noel G. Morgan, Marius K. Lemberg and Mark Peakman

Copy Of -Spatiotemporal Dynamics of Insulitis in Human Type 1 Diabetes

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Wedgewood KC, Richardson SJ, Morgan NG, Tsaneva-Atanasova K

Introducing the Endotype Concept to Address the Challenge of Disease Heterogeneity in Type 1 Diabetes

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Mauuela Battaglia, Simi Ahmed, Mark S.Anderson, Mark A.Atkinson, Dorothy Becker, Polly J. Bingley, Emanuele Bosi, Todd M. Brusko, Linda A. Dimeglia, Carmella Evans-Molina, Stephen E. Gitelman, Carla J. Greenbaum, Peter A. Gottlied, Kevan C. Herold, Martin J. Hessner, Mikael Knip, Laura Jacobsen, Jeffery P. Krischer, S. Alice Long, Markus Lundgren, Eoin F. McKinney, Noel G. Morgan, Richard A. Oram, Tomi Pastinen, Michael C. Peters, Alessandra Petrelli, Xiaoning Qian, Maria J. Redondo, Bart O. Roep, Desmond Schatz, David Skibinski, Mark Peakman

Potential of mesenchymal stromal cell secretory factors induce sustained improvements in islet function pre- and post-transplantation

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Chloe L Rackham, Stefan Amisten, Shanta J persaud, Aileen J F King, Peter M Jones

Islet cell hyperexpression of HLA class 1 antigens : a defining feature in type 1 diabetes

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Sarah J. Richardson, Teresa Rodriguez-Calvo, Ivan C. Gerling, Clayton E. Mathews, John S. Kaddis, Mark A. Russell, Marie Zeissler, Pia Leete, Lars Krogvold, Knut Dahl-Jørgensen, Matthias von Herrath, 

Alberto Pugliese, Mark A. Atkinson, Noel G. Morgan

Differential Insulitic Profiles Determine the Extent of β-Cell Destruction and the Age at Onset of Type 1 Diabetes.

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Leete P, Willcox A, Krogvold, Dahl-Jørgensen, Foulis, Richardson SJ, Morgan NG.

Annexin A1 Is a Key Modulator of Mesenchymal Stromal Cell–Mediated Improvements in Islet Function

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Chloe L.Rackham, Andreia E. Vargas, Ross G.Hawkes, Stefan Amisten, Shanta J. Persaud, Amazon L.F.Austin, Aileen J.F.King, Peter M.Jones

The Subcellular distribution of cylin - D1 and cyclin - D3 within human islet cells varies according to the status of the pancreas donor.

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Taniguchi K, M.A. Russell, Morgan NG, Richardson SJ.

 

Islet Inflammation in Human Type 1 Diabetes Mellitus

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Morgan NG, Leete P, Foulis AK, Richardson SJ. 

Detection of a low-grade enteroviral infection in the islets of Langerhans of living patients newly diagnosed with type 1 diabetes.

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Krogvold L, Edwin B, Buanes T, Frisk G, Skog O, Anagandula M, Korsgren O, Undien D, Eike MC, Rochardson SJ, Leete P, Morgan NG, Oikarinen S, Oikarinen M, Laiho JE, Hyöty H, Ludviqsson J, Hanssen KF, Dahl - Dahl-Jørgensen K.  

Blood and islet phenotypes indicate immunological heterogeneity in type 1 diabetes.

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 Arif S, Leete P, Richardson SJ, Nquyen V, Marks K, nor NM, Estorninho M, Kronenberg - Versteeq D, Bingley PJ, Todd JA, Guy C, Dunger DB, Powrie J, Wilcox A, Foulis AK, Rchardson SJ, de Rinaldis E, Morgan NG, Lorenc A, Peakman M.  

Enteroviruses as causative agents in type 1 diabetes: loose ends or lost cause?

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Morgan NG,Richardson SJ.

Infection of human islets of langerhans with two strains of Coxsackie B virus serotype 1: assessment of virus replication, degree of cell death and induction of genes involved in the innate immunity pathway.

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Anagandula M, Richardson SJ, Oberste MS, Sioofy-Khojine AB, Hyöty H, Morgan NG, Korsgren O, Frisk G. 

Activating germline mutations in STAT3 cause early-onset multi-organ autoimmune disease.

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Flanagan SE, Haapaniemi E, Russell M, Caswell R, Lango Allen H, De Franco E, McDonald TJ, Rajala H4, Ramelius A, Barton J, Heiskanen K, Heiskanen-Kosma T, Kajosaari M, Murphy NP, Milenkovic T, Seppänen M, Lernmark Å, Mustjoki S, Otonkoski T, Kere J, Morgan NG, Ellard S, Hattersley AT.

GPR120 (FFAR4) is preferentially expressed in pancreatic delta cells and regulates somatostatin secretion from murine islets of Langerhans.

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Stone VM, Dhayal S, Brocklehurst KJ, Lenaghan C, Sörhede Winzell M, Hammar M, Xu X, Smith DM, Morgan NG.

The impact of anti-inflammatory cytokines on the pancreatic β-cell.

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Russell MA, Morgan NG.

Detection of enterovirus in the islet cells of patients with type 1 diabetes: what do we learn from immunohistochemistry? Reply to Hansson SF, Korsgren S, Pontén F et al [letter].

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Richardson SJ1, Leete P, Dhayal S, Russell MA, Oikarinen M, Laiho JE, Svedin E, Lind K, Rosenling T, Chapman N, Bone AJ; nPOD-V Consortium, Foulis AK, Frisk G, Flodstrom-Tullberg M, Hober D, Hyoty H, Morgan NG.

Copy Of -Pancreatic pathology in type 1 diabetes mellitus

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Richardson SJ, Leete P, Morgan NG, Foulis AK

Copy Of -Evaluation of the fidelity of immunolabelling obained with clone 5D8/1, a monoclonal antibody directed against the enteroviral capsid protein, VP1 in human pancreas

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Richardson SJ1, Leete P, Dhayal S, Russell MA, Oikarinen M, Laiho JE, Svedin E, Lind K, Rosenling T, Chapman N, Bone AJ; nPOD-V Consortium, Foulis AK, Frisk G, Flodstrom-Tullberg M, Hober D, Hyoty H, Morgan NG.

Co-transplantation of mesenchymal stem cells maintains islet organisation and morphology in mice

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C.L.Rackham, P.C.Chagastelles, N.B.Nardi, A.C.Hauge-Evans, P.M.Jones, A.J.F.King

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