RECENT PUBLICATIONS

Histological validation of a type 1 diabetes clinical diagnostic model for classification of diabetes.

A.L.J.Carr, D.J.Perry, A.L.Lynam, S Chamala, C.S.Flaxman, S.A.SHarp, L.A.Ferrat, A.G.Jones, M.L.Beery, L.M.Jacobsen, C.H.Wasserfall, M.L.Campbell-Thompson, I.Kusmartseva, A.Posgai, D.A.Schatz, M.A.Atkinson, T.M.Brusko, S.J.Richardson, B.M.Shields, R.A.Oram

Diabetic Medicine 7 July 2020 https://doi.org/10.1111/dme.14361

Vitamin D-binding protein contributes to the maintenance of α-cell morphology and function

Katrina Viloria, Daniela Nasteska, Linford J.B.Briant, Silke Heising, Dean P.Larner, Nicholas H.F.Fine, Fiona B. Ahsford, Gabriela da Silva Xavier, Maria Jiménez Ramos, Annie Hasib, Federica Cuozzo, Jocelyn E. Manning Fox, Patrick E,MacDonald, Iidem Akerman, Gareth G.Lavery, Christine Flaxman, Noel G. Morgan, Sarah J. Richardson, David J.Hodson

Cell Reports 16 June 2020 https://doi.org/10.1016/j.celrep.2020.107761

American Journal of Endocrinology & Metabolism 1st June 2020 https://doi.org/10.1152/ajpendo.00372.2019

An integrated multi-omics approach identifies the landscape of interferon-α-mediated responses of human pancreatic beta cells.

Maikel L. Colli, Mireia Ramos-Rodríguez,Ernesto S . Nakayasu, Matia I.Alvelos, Miguel Lopes, Jessica L.E.Hill, Jean-Valery Turantsinze, Alexandra Coomans de Brachène, Mark A Russell, Helena Raurell-Vila, Angela Castela, Jonàs Juan-Mateu, Bobbie-Jo M. Webb-Robertson, Lars Krogvold, Knut Dahl-Jorgenses, Lorella Marselli, Piero Marchetti, Sarah J Richardson, Noel G Morgan, Thomas O.Metz, Lorenzo Pasquali, Décio L. Eizirik.

Nature Communications 22nd May 2020 Article number: 2584 (2020)

Reduced Expression of the Co-regulator TLE1 in Type 2 Diabetes Is Associated with Increased Islet α-Cell Number

Sarah L Armour, Scott J Anderson, Sarah J Richardson, Yuchun Ding, Chris Carey, James Lyon, Rashmi R Maheshwari, Najwa Al-Jahdami, Natalio Krasnogor, Noel G Morgan

Endocrinology April 2020 https://doi.org/10.1210/endocr/bqaa011

Optimizing beta cell function through mesenchymal stromal cell-mediated mitochondria transfer

Chloe L Rackham, Ella L Hubber, Anna Czajka, Afshan N Malik, Pete M Jones

Stem Cells 20th April 2020 doi: 10.1002/stem.3134.

Studies of insulin and proinsulin in pancreas and serum support the existence of aetiopathological endotypes of type 1 diabetes associated with age at diagnosis

Pia Leete, Richard A Oram, Timothy J McDonald, Beverley M Shields, Clemens Ziller, TIGI Study Team, Andrew T Hattersley, Sarah J Richardson, Noel G Morgan

Diabetologia 15 March 2020

Rationale for enteroviral vaccination and antiviral therapies in human type 1 diabetes.

Jessica L Dunne, Srah J Richardson, Mark A Atkinson, Maria E Craig, Knut Dahl-Jørgensen, Malin Flodström-Tullberg, Heikki Hyöty, Richard A Insel, Åke Lernmark, Richard E Lloyd, Noel G Morgan, Alberto Pugliese

Diabetologia May 2019 doi: 10.1007/s00125-019-4811-7.

Upregulation of HLA Class I and Antiviral Tissue Responses in Hashimoto's Thyroiditis

Therese Wieder, Sarah J Richardson, Noel G Morgan, Trond H Paulsen, Knut Dhal-Jørgensen, Sara Salehi Hammerstad

Thyroid March 2020 doi: 10.1089/thy.2019.0607

In Situ Analysis Reveals That CFTR Is Expressed in Only a Small Minority of β-Cells in Normal Adult Human Pancreas

Michael G. White, Rashmi R Maheshwari, Scott J Anderson, Rolando Berlinguer - Palmini, Claire Jones, Sarah J Richardson, Pavana G Rotti, Sarah L Armour, Yuchun Ding, Natalio Krasnogor, John F Engelhardt, Mike A gray, Noel G Morgan, James A M Shaw

J Clin Endocrinol Metab May 2020 doi: 10.1210/clinem/dgz209.

Differential effects of saturated and unsaturated fatty acids on autophagy in pancreatic β-cells

Shalinee Dhayal, Francesco P Zummo, Matthew W Andreson, Patricia Thomas, Hannah J Welters, Catherine Arden, Noel G Morgan

J Mol Endocrinol November 2019 doi: 10.1530/JME-19-0096.

Evidence that a STAT3 Mutation Causing Hyper IgE Syndrome Leads to Repression of Transcriptional Activity

Sameer Bahal, Maha E Houssen, Ania Manson, Lorena Lorenzo, Mark A. Russell, Noel G Morgan, Fariba Tahami, Sofia Grigoriadou

13th October 2019 Immunol doi :10.1155/2019/1869524.

What the HLA-I! – Classical and Non-classical HLA Class I and Their Potential Roles in Type 1 Diabetes

Rebecca C.Wyatt, Giacomo Lanzoni, Mark A. Russell, Van Gerling & Sarah Richardson

Springer 9th December 2019

Molecular Pathways for Immune Recognition of Preproinsulin Signal Peptide in Type 1 Diabetes Diabetes 2018 Jan; db170021

Deborah Kronenberg-Versteeg, Martin Eichmann, Mark A. Russell, Arnoud de Ru, Beate Hehn, Norkhairin Yusuf, Peter A. van Veelen, Sarah J. Richardson, Noel G. Morgan, Marius K. Lemberg and Mark Peakman

Diabetes 2018 Jan; db170021

Copy Of -Spatiotemporal Dynamics of Insulitis in Human Type 1 Diabetes

Wedgewood KC, Richardson SJ, Morgan NG, Tsaneva-Atanasova K

Front Physiol Dec 27/7: 633

Introducing the Endotype Concept to Address the Challenge of Disease Heterogeneity in Type 1 Diabetes

Mauuela Battaglia, Simi Ahmed, Mark S.Anderson, Mark A.Atkinson, Dorothy Becker, Polly J. Bingley, Emanuele Bosi, Todd M. Brusko, Linda A. Dimeglia, Carmella Evans-Molina, Stephen E. Gitelman, Carla J. Greenbaum, Peter A. Gottlied, Kevan C. Herold, Martin J. Hessner, Mikael Knip, Laura Jacobsen, Jeffery P. Krischer, S. Alice Long, Markus Lundgren, Eoin F. McKinney, Noel G. Morgan, Richard A. Oram, Tomi Pastinen, Michael C. Peters, Alessandra Petrelli, Xiaoning Qian, Maria J. Redondo, Bart O. Roep, Desmond Schatz, David Skibinski, Mark Peakman

Diabetes Care January 2020 https://doi.org/10.2337/dc19-0880

Potential of mesenchymal stromal cell secretory factors induce sustained improvements in islet function pre- and post-transplantation

Chloe L Rackham, Stefan Amisten, Shanta J persaud, Aileen J F King, Peter M Jones

December 2018 Cytotherapy doi: 10.1016/j.jcyt.2018.07.007.

Islet cell hyperexpression of HLA class 1 antigens : a defining feature in type 1 diabetes

Sarah J. Richardson, Teresa Rodriguez-Calvo, Ivan C. Gerling, Clayton E. Mathews, John S. Kaddis, Mark A. Russell, Marie Zeissler, Pia Leete, Lars Krogvold, Knut Dahl-Jørgensen, Matthias von Herrath, 

Alberto Pugliese, Mark A. Atkinson, Noel G. Morgan

Diabetologia Nov 59(11): 2448-58, 2016

Differential Insulitic Profiles Determine the Extent of β-Cell Destruction and the Age at Onset of Type 1 Diabetes.

Leete P, Willcox A, Krogvold, Dahl-Jørgensen, Foulis, Richardson SJ, Morgan NG.

Diabettes 65: 1362–1369,2016

Annexin A1 Is a Key Modulator of Mesenchymal Stromal Cell–Mediated Improvements in Islet Function

Chloe L.Rackham, Andreia E. Vargas, Ross G.Hawkes, Stefan Amisten, Shanta J. Persaud, Amazon L.F.Austin, Aileen J.F.King, Peter M.Jones

Diabetes January 2016 doi.10.2337

The Subcellular distribution of cylin - D1 and cyclin - D3 within human islet cells varies according to the status of the pancreas donor.

Taniguchi K, M.A. Russell, Morgan NG, Richardson SJ.

 

Diabetologia 58: 2056–20631,2015

Islet Inflammation in Human Type 1 Diabetes Mellitus

Morgan NG, Leete P, Foulis AK, Richardson SJ. 

IUBMB Life;66:723-734, 2014 11

Detection of a low-grade enteroviral infection in the islets of Langerhans of living patients newly diagnosed with type 1 diabetes.

Krogvold L, Edwin B, Buanes T, Frisk G, Skog O, Anagandula M, Korsgren O, Undien D, Eike MC, Rochardson SJ, Leete P, Morgan NG, Oikarinen S, Oikarinen M, Laiho JE, Hyöty H, Ludviqsson J, Hanssen KF, Dahl - Dahl-Jørgensen K.  

Diabetes; 64:1682-1687,2015

Blood and islet phenotypes indicate immunological heterogeneity in type 1 diabetes.

 Arif S, Leete P, Richardson SJ, Nquyen V, Marks K, nor NM, Estorninho M, Kronenberg - Versteeq D, Bingley PJ, Todd JA, Guy C, Dunger DB, Powrie J, Wilcox A, Foulis AK, Rchardson SJ, de Rinaldis E, Morgan NG, Lorenc A, Peakman M.  

Diabetes;64:1682-1687, 2015

Enteroviruses as causative agents in type 1 diabetes: loose ends or lost cause?

Morgan NG,Richardson SJ.

Trends Endocrinol Metab;25:611-619,2014

Infection of human islets of langerhans with two strains of Coxsackie B virus serotype 1: assessment of virus replication, degree of cell death and induction of genes involved in the innate immunity pathway.

Anagandula M, Richardson SJ, Oberste MS, Sioofy-Khojine AB, Hyöty H, Morgan NG, Korsgren O, Frisk G. 

J Med Virol;86:1402-1411, 2014

Activating germline mutations in STAT3 cause early-onset multi-organ autoimmune disease.

Flanagan SE, Haapaniemi E, Russell M, Caswell R, Lango Allen H, De Franco E, McDonald TJ, Rajala H4, Ramelius A, Barton J, Heiskanen K, Heiskanen-Kosma T, Kajosaari M, Murphy NP, Milenkovic T, Seppänen M, Lernmark Å, Mustjoki S, Otonkoski T, Kere J, Morgan NG, Ellard S, Hattersley AT.

Nat Genet;46:812-814, 2014

GPR120 (FFAR4) is preferentially expressed in pancreatic delta cells and regulates somatostatin secretion from murine islets of Langerhans.

Stone VM, Dhayal S, Brocklehurst KJ, Lenaghan C, Sörhede Winzell M, Hammar M, Xu X, Smith DM, Morgan NG.

Diabetologia;57:1182-119, 2014

The impact of anti-inflammatory cytokines on the pancreatic β-cell.

Russell MA, Morgan NG.

Islets;6:e950547, 2014

Detection of enterovirus in the islet cells of patients with type 1 diabetes: what do we learn from immunohistochemistry? Reply to Hansson SF, Korsgren S, Pontén F et al [letter].

Richardson SJ1, Leete P, Dhayal S, Russell MA, Oikarinen M, Laiho JE, Svedin E, Lind K, Rosenling T, Chapman N, Bone AJ; nPOD-V Consortium, Foulis AK, Frisk G, Flodstrom-Tullberg M, Hober D, Hyoty H, Morgan NG.

Diabetologia;57:647-649, 2014

Copy Of -Pancreatic pathology in type 1 diabetes mellitus

Richardson SJ, Leete P, Morgan NG, Foulis AK

Endochrine Pathology 25 80-92, 2014

Copy Of -Evaluation of the fidelity of immunolabelling obained with clone 5D8/1, a monoclonal antibody directed against the enteroviral capsid protein, VP1 in human pancreas

Richardson SJ1, Leete P, Dhayal S, Russell MA, Oikarinen M, Laiho JE, Svedin E, Lind K, Rosenling T, Chapman N, Bone AJ; nPOD-V Consortium, Foulis AK, Frisk G, Flodstrom-Tullberg M, Hober D, Hyoty H, Morgan NG.

Diabetologia 57: 392-401, 2014

Co-transplantation of mesenchymal stem cells maintains islet organisation and morphology in mice

C.L.Rackham, P.C.Chagastelles, N.B.Nardi, A.C.Hauge-Evans, P.M.Jones, A.J.F.King

Diabetalogia 26 January 2011

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